Katanin P60 Targets Microtubules with Defects
نویسندگان
چکیده
منابع مشابه
The role of katanin p60 in breast cancer bone metastasis
p60 is a subunit of katanin involved in microtubule-severing. Previous studies of p60 were primarily focused on microtubule regulation and cell cycle regulation. More recent research has demonstrated that katanin p60 possesses a function in prostate cancer bone metastasis; however, its role in breast cancer bone metastasis remains unclear. In the present study, immunohistochemistry was used to ...
متن کاملN-terminal phosphorylation of p60 katanin directly regulates microtubule severing.
Proteins of the AAA (ATPases associated with various cellular activities) family often have complex modes of regulation due to their central position in important cellular processes. p60 katanin, an AAA protein that severs and depolymerizes microtubules, is subject to multiple modes of regulation including a phosphorylation in the N-terminal domain involved in mitotic control of severing. Phosp...
متن کاملCell Migration: Katanin Gives Microtubules a Trim
New evidence suggests that katanin - best known for severing microtubules in their more stable regions - localizes at the leading edge of migratory cells and trims microtubules at their dynamic plus ends.
متن کاملAxonal growth is sensitive to the levels of katanin, a protein that severs microtubules.
Katanin is a heterodimeric enzyme that severs microtubules from the centrosome so that they can move into the axon. Katanin is broadly distributed in the neuron, and therefore presumably also severs microtubules elsewhere. Such severing would generate multiple short microtubules from longer microtubules, resulting in more microtubule ends available for assembly and interaction with other struct...
متن کاملKatanin p60 promotes neurite growth and collateral formation in the hippocampus.
OBJECTIVE This study aimed to investigate the effect of Katanin p60 on the neurite growth and collateral formation in the hippocampus. METHODS Gene cloning was performed to construct the Katanin p60 eukaryotic vector. The microtubule cutting effect and protein expression of Katanin p60 were investigated in 293T cells. Then, these vectors were transfected into hippocampal neurons of rats, and ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2012
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2011.11.3806